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KMID : 1134820150440060816
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Journal of the Korean Society of Food Science and Nutrition
2015 Volume.44 No. 6 p.816 ~ p.822
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Induction of Apoptosis by Gamma-Irradiated Apigenin in H1975 Human Non-Small Lung Cells
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Park Jae-Nam
Byun Eui-Baek
Kim Jwa-Jin
Jang Beom-Su
Park Sang-Hyun
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Abstract
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The objective of this study was to evaluate the anticancer effects of gamma-irradiated apigenin against various human cancer cells. Structural changes were analyzed by high pressure liquid chromatography. Gamma-irradiated apigenin showed a new peak distinguished from the main peak of apigenin (non-irradiated). Cytotoxic effects in human normal cells (HS68) were not observed upon gamma-irradiated and non-irradiated apigenin treatment. However, gamma-irradiated apigenin treatment significantly increased cytotoxicity against non-small lung cancer cells. For apoptosis induction activity tested by Annexin V/PI staining, gamma-irradiated apigenin showed a stronger effect than non-irradiated apigenin, and the level of reactive oxygen species was apparently elevated by gamma-irradiated apigenin treatment. These results suggest that gamma irradiation could be an effective method for development of a new physiological compound from an original compound by inducing structural changes.
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KEYWORD
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gamma irradiation, apigenin, non-small cell lung cancer, apoptosis, reactive oxygen species
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